Two sample MR report
TMEM176B_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | 0.0551266 | 0.2179661 | 0.8076015 |
| Weighted median | 9 | -0.0259184 | 0.0222177 | 0.2433872 |
| Inverse variance weighted | 9 | -0.0438448 | 0.0175330 | 0.0123946 |
| Simple mode | 9 | -0.0176233 | 0.0371239 | 0.6476780 |
| Weighted mode | 9 | -0.0181247 | 0.0356016 | 0.6244247 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.097032 | 7 | 0.7685358 |
| Inverse variance weighted | 4.304553 | 8 | 0.8286536 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0609778 | 0.1338572 | 0.6625123 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003172 | 0 | TRUE | 0.0904986 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
